Professional Strength Curcumin with CurQfen™ is the best answer for getting free, unconjugated (unrestricted) curcumin to where it is needed in your body.

Professional Strength Curcumin with CurQfen™ is a combination of purified curcuminoids and fenugreek fiber, referred to technically as curcumin-galactomannan (CGM). These are not simply thrown together into the capsule. In the processing of Professional Strength Curcumin with CurQfen™ purified fenugreek fiber is hydrated to form a gel. Then the curcumin is impregnated into the gel using sonication methods which micronizes the curcumin particles and imbeds them deeply into the gel. The gel is then dehydrated and powdered for stabilization. When you consume the capsule the gel is rehydrated and curcumin is slowly released into the GI tract. This slow release from the gel appears to allow most of the curcumin to bypass conjugation (metabolism into less active forms of curcumin which are quickly cleared from the liver) and get into the bloodstream in the free curcumin form.

How is CurQfen™ better than other formulations?

There are 2 problems with getting good effects from curcumin:

Absorption from the GI tract is low
Metabolism of curcumin in body very quick—very low levels of “free” (unmetabolized, unconjugated) curcumin in body

CurQfen™ answers both of these questions. Not only is absorption high, but it is in the free form that is more biologically beneficial. Blood levels of free curcumin after taking even low doses of 100 or 400 mg are higher than seen by much higher doses of other products on the market, as shown in the Figure.

Curcumin is sometimes sold with piperine added to improve absorption. This result is shown in the Figure. The peak for this product is 180 ng/ml, which is far below the 440 ng/ml seen with CurQfen™. Other products may be advertised as being much more bioavailable than standard curcumin, but when you look at the blood levels in volunteers who have taken curcumin, the levels are very, very low, as seen with Brand B and Brand C in the Figure below. But 12 hours after taking CurQfen™ there is still about 100 ng/ml, which is higher than the peak levels of many other products.

Many companies do not even report the levels of free curcumin after taking their product. The Figure shows free curcumin levels for companies that have published the research data.

What is the proof that CurQfen™ works?

Bioavailability study with 50 people. (Kumar et al., 2016)
45-fold increase in bioavailability compared to standard curcumin. Also found that 76% of the absorbed curcumin was in the bioactive, free form which readily crosses membranes into cells. Most formulas only have single digit percentages of the curcumin available as free curcumin. Conjugation (metabolism for elimination from body) happens very quickly with almost all other formulas.

Brain and organ concentrations in mice (Krishnakumar et al., 2015)
Found between 200 and 450 ng/g tissue of free curcumin in brain, heart, liver, kidney and spleen. Standard curcumin only 1.4±0.8 ng/g in same organs. This is proof that CurQfen™ is absorbed into the body in the free unconjugated form that is readily absorbed throughout the body, including into the brain.

Multiple sclerosis mouse model. (Ittiyavirah and Hema, 2019)
In a mouse model where MS-like symptoms were induced researchers found that CurQfen™ provided significant neuroprotection and remyelination. This study demonstrates the effectiveness of CurQfen™ delivery into the central nervous system and brain.

CurQfen™ effect on brain waves is consistent with brain penetration. (Khanna et al., 2020a)
The curcumin-galactomannan complex (CurQfen™) increased α and β waves and reduced the ratio of α/β waves. People taking the CurQfen™ also had a reduced audio-reaction time and choice-based visual reaction time after 30 days of 500 mg twice a day of CurQfen™. This is evidence that clinically significant amounts of curcumin can cross the blood-brain barrier to help with inflammation in the brain and contribute to the normal physicochemical functioning of the brain.

CurQfen™ improves liver function in chronic alcoholics. (Krishnareddy et al., 2018)
48 chronically alcoholic men took part in this 8-week randomized, placebo-controlled clinical trial. The active group was given 250 mg of CurQfen™ twice a day. Liver enzyme levels improved, the body’s own antioxidant enzymes (glutathione, super oxide dismutase, glutathione peroxidase) increased activity, lipid peroxidation marker TBARS decreased and inflammation markers decreased. Differences were all significant between the CurQfen™ and placebo group.

CurQfen™ works better than standard curcumin for alleviating effects of alcohol on liver. (Mohan et al., 2019)
In this 30-day test in Wistar rats alcohol caused significant elevated liver toxicity markers, lipid peroxidation, and inflammatory markers with a simultaneous decrease in antioxidant defenses. Supplementing with CurQfen™ reversed all of the pathological effects of the alcohol, almost close to normal levels. Microscopic rexamination of the liver also showed the benefits of CurQfen™. Results were significantly better with CurQfen™ than with standard curcumin.

Reduction of arterial stiffness in young obese men. (Campbell et al., 2017)
Young, obese men who started a randomized, placebo-controlled 12-week trial with stiff arteries, measured with cfPWV (carotid-femoral Pulse Wave Velocity), took 500 mg of CurQfen™ per day and normalized their arterial stiffness. Their pulse pressure, the difference between systolic and diastolic blood pressure, was also significantly reduced by the CurQfen™. These changes in stiffness in large arteries and lower pulse pressure indicate a reduced risk of cardiovascular disease events.

CurQfen™ helps manage stress, anxiety and fatigue. (Sudheeran et al., 2016)
In a randomized controlled trial of 60 men experiencing stress, anxiety and fatigue from their jobs took either a placebo or 500 mg of CurQfen™ twice a day. Self-administered scales showed significant reductions in fatigue, anxiety and stress and an improvement in quality of life after 30 days. The improvements were correlated with significant enhancements in activities of antioxidant enzymes and a reduction in lipid peroxidation. Testing in this study group reaffirmed the improved absorption of free curcuminoids (30 to 39-fold better) compared to standard curcumin.

Protects neurons from pesticide toxicity. (Sindhu et al., 2020)
Rats were treated with carbofuran for 90 days to induce a chronic nerve-toxic state. Rats were then given placebo, standard curcumin or CurQfen™ for another 30 days. Standard curcumin and CurQfen™ both had an effect on reversing the toxicity, oxidative stress and mitochondrial dysfunction due to carbofuran. However, the CurQfen™ was much more effective, comparable to results in normal rats.

Ulcerative colitis amelioration in rat model. (Sheethal et al., 2020)
Rats were induced into a model for ulcerative colitis and then treated with a drug, standard curcumin or CurQfen™. The CurQfen™ significantly enhanced endogenous antioxidant activities and decreased the levels of inflammatory markers and suppressed the genetic expression (mRNA levels) of inflammatory markers. The authors stated that CurQfen™ “exerts marked curative effects on acute experimental colitis.”

Osteoarthritis of the knee alleviated by CurQfen™. Results almost double the effect of glucosamine hydrochloride / chondroitin sulfate. (Khanna et al., 2020b)
In India 80 adults with confirmed osteoarthritis in the knees were assigned to either a combination of 400 mg of CurQfen™ with 500 mg of glucosamine hydrochloride or a combination of 500 mg of glucosamine hydrochloride and 415 mg of chondroitin sulfate. Tests were conducted at 0, 28 and 84 days comparing the two treatments. There were improvements in walking performance, improved inflammatory markers and improvements in osteoarthritic specific scores (WOMAC, VAS, KPS) for both treatments, but the group that took CurQfen™ has about double the effect of the other glucosamine / chondroitin group. For example, in the uphill walking treadmill test the glucosamine / CurQfen™ group went from an average of 92 m at baseline to 378 m at 84 days (an improvement of 285 m), while the glucosamine / chondroitin group went from 98 m at baseline to 188 m at 84 days (an improvement of 90 m).

Osteoarthritis of the knee improved with CurQfen™. (Thomas et al., 2020)
A 6-week test of 84 people with knee osteoarthritis were given 400 mg of CurQfen™ or a combination of 415 mg of chondroitin sulfate / 500 mg of glucosamine hydrochloride. The results for the CurQfen™ were superior to the chondroitin / glucosamine treatment for walking performance, osteoarthritis-specific scores and decreased serum inflammatory markers. The treadmill walking scores went from an average of 106 m at baseline to 326 m (difference of 220 m) in the CurQfen™ group after 42 days, compared to 98 m to 183 m (a difference of 85 m) in the chondroitin / glucosamine group after 42 days. So, even the relatively low dose of 400 mg of CurQfen™ showed great efficacy in helping people quickly overcome pain and dysfunction due to knee osteoarthritis.

References

Campbell, M.S., Berrones, A.J., Krishnakumar, I.M., Charnigo, R.J., Westgate, P.M., Fleenor, B.S., 2017. Responsiveness to curcumin intervention is associated with reduced aortic stiffness in young, obese men with higher initial stiffness. J. Funct. Foods 29, 154–160. https://doi.org/10.1016/j.jff.2016.12.013

Ittiyavirah, S.P., Hema, S., 2019. Ameliorating demyelination effect of curqfen® in cuprizone induced mice model of multiple sclerosis. Pharm. Pharmacol. Int. J. 7. https://doi.org/10.15406/ppij.2019.07.00227

Khanna, A., Das S, S., Kannan, R., Swick, A.G., Matthewman, C., Maliakel, B., Ittiyavirah, S.P., Krishnakumar, I.M., 2020a. The effects of oral administration of curcumin-galactomannan complex on brain waves are consistent with brain penetration: a randomized, double-blinded, placebo-controlled pilot study. Nutr. Neurosci. 1–10. https://doi.org/10.1080/1028415X.2020.1853410

Khanna, A., Das, S.S., Smina, T.P., Thomas, J.V., Kunnumakkara, A.B., Maliakel, B., Krishnakumar, I.M., Mohanan, R., 2020b. Curcumagalactomannoside/Glucosamine Combination Improved Joint Health Among Osteoarthritic Subjects as Compared to Chondroitin Sulfate/Glucosamine: Double-Blinded, Randomized Controlled Study. J. Altern. Complement. Med. 26, 945–955. https://doi.org/10.1089/acm.2020.0128

Krishnakumar, I., Maliakel, A., G, G., Kumar, D., Maliakel, B., Kuttan, R., 2015. Improved blood–brain-barrier permeability and tissue distribution following the oral administration of a food-grade formulation of curcumin with fenugreek fibre. J. Funct. Foods 14, 215–225. https://doi.org/10.1016/j.jff.2015.01.049

Krishnareddy, N.T., Thomas, J.V., Nair, S.S., N. Mulakal, J., Maliakel, B.P., Krishnakumar, I.M., 2018. A Novel Curcumin-Galactomannoside Complex Delivery System Improves Hepatic Function Markers in Chronic Alcoholics: A Double-Blinded, randomized, Placebo-Controlled Study. BioMed Res. Int. 2018, e9159281. https://doi.org/10.1155/2018/9159281

Kumar, D., Jacob, D., Ps, S., Maliakkal, A., Nm, J., Kuttan, R., Maliakel, B., Konda, V., Krishnakumar, I.M., 2016. Enhanced bioavailability and relative distribution of free (unconjugated) curcuminoids following the oral administration of a food-grade formulation with fenugreek dietary fibre: A randomised double-blind crossover study. J. Funct. Foods 22, 578–587. https://doi.org/10.1016/j.jff.2016.01.039

Mohan, R., Jose, S., Sukumaran, S., S, A., S, S., John, G., M, K.I., 2019. Curcumin-galactomannosides mitigate alcohol-induced liver damage by inhibiting oxidative stress, hepatic inflammation, and enhance bioavailability on TLR4/MMP events compared to curcumin. J. Biochem. Mol. Toxicol. 33, e22315. https://doi.org/10.1002/jbt.22315

Sheethal, S., Ratheesh, M., Jose, S.P., Asha, S., Krishnakumar, I.M., Sandya, S., Girishkumar, B., Grace, J., 2020. Anti-Ulcerative Effect of Curcumin-Galactomannoside Complex on Acetic Acid-Induced Experimental Model by Inhibiting Inflammation and Oxidative Stress. Inflammation 43, 1411–1422. https://doi.org/10.1007/s10753-020-01218-9

Sindhu, E.R., Binitha, P.P., Saritha, S.N., Balu, M., Kuttan, R., Krishnakumar, I.M., 2020. Comparative neuroprotective effects of native curcumin and its galactomannoside formulation in carbofuran-induced neurotoxicity model. Nat. Prod. Res. 34, 1456–1460. https://doi.org/10.1080/14786419.2018.1514401

Sudheeran, S.P., Jacob, D., Natinga Mulakal, J., Gopinathan Nair, G., Maliakel, A., Maliakel, B., Kuttan, R., Im, K., 2016. Safety, Tolerance, and Enhanced Efficacy of a Bioavailable Formulation of Curcumin With Fenugreek Dietary Fiber on Occupational Stress: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. J. Clin. Psychopharmacol. 36, 236–243. https://doi.org/10.1097/JCP.0000000000000508

Thomas, J.V., Smina, T.P., Khanna, A., Kunnumakkara, A.B., Maliakel, B., Mohanan, R., Krishnakumar, I.M., 2020. Influence of a low-dose supplementation of curcumagalactomannoside complex (CurQfen) in knee osteoarthritis: A randomized, open-labeled, active-controlled clinical trial. Phytother. Res. PTR. https://doi.org/10.1002/ptr.6907

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