No this is not new math, nor is it even just estimating. This is what happens when two substances come together. The end results are greater than the two individually. This is called synergy. Have you ever actually read much information about the true “reality” of what happens when two toxic substances combine in your body? Probably not since most “studies” and “tests” are only performed on one substance at a time. We are going to give you a two-part blog on the “positive” aspects of something known as synergy and the “negative” aspects of synergy as well. This article will discuss how synergy works when combining toxic substances. Next week you will be pleasantly surprised at the positive effects synergy has when combining two healthful substances. Synergism comes from the Greek word "synergos" meaning working together. A synergistic effect is the situation where the combined effect of two items is much greater than the sum of the effects of each agent given alone. (A type of "when is one plus one greater than two" effect). For example: Exposure to mercury has been tested and is known to cause certain detrimental effects on the body. However, have you ever seen the results of mercury with lead? The results are astounding.
- Mercury will kill 1 out of 100 rats.
- Lead will kill 1 out of 100 rats.
- Combine them and 100% of exposed rats will die.
- Consumed sugar while unintentionally inhaling second hand cigarette smoke?
- Received a vaccination? (the very fact that you have testosterone in your body can set you up for a reaction)
- Eaten food that is not only conventionally grown (meaning it may have added hormones) but is also genetically modified?
- Consumed both sugar and food coloring?
- Used over the counter drugs and may already have heavy metal toxicity?
- Had an antibiotic knowing you also suffer from candida?
A Few Examples of Daily Stressors Are:
- Automotive exhaust
- Cleaning products
- Chemicals in treated water
- Consumption of alcohol or tobacco
- Environmental pollution
- Insect repellents
- Prescription drugs
- Psychological stress
- Social stress
- Ultraviolet radiation
- Whole-body vibration
- Consequences that may be significantly different than would be expected from individual exposures.
- A range of combined acute and chronic effects.
- Effects that can appear immediately or sometime later.
- Increased or unexpected harmful effects — including entirely new kinds of effects.
- What color are your paper towels?
- What color of muffin liners do you use?
- Do you use aluminum cookie sheets, rice cooker or other cooking apparatus?
- Where do you store your cleaning supplies? Are they toxic?
- Do you use dryer sheets?
- Do you use lead based candles for burning?
- Do you use air purifiers—from a can, electrical or otherwise?
- What color is your toilet paper?
- What color are your tissues?
- What type of container do you carry your water in?
- Take a few minutes and explore everything that comes in contact with your skin.
- Plastic bottles and heat
- Fluoride and aluminum
- Non-stick pans and heat
- Mercury with water
- Food coloring and aspartame
- Food coloring with MSG or any other neurotoxin
- Mercury with aluminum
- Mercury with testosterone Using current methods, laboratory tests for synergistic and cumulative effects, are impractical because of the high costs in time and money that would be required. Testing just one dose of the top 1,000 high volume chemicals in three-way combinations would require 166 million different experiments. Testing all the three-way combinations would take over 180 years to complete, if each experiment took one hour to conduct and 100 laboratories worked non-stop. Lack of Testing Not only are current scientific methods not well-suited to studying the safety of combinations of chemicals, the individual chemical testing we do perform is woefully inadequate in relation to the real world. Most chemicals that are used in commerce have not been lab tested. Nor have they been the focus of an epidemiological study to look for evidence of harmful effects in humans. How many of the 75,000 chemicals in commerce have actually been tested for their toxicity? The Environmental Defense analyzed a sample of 100 chemicals out of a total number of 3,000 high production volume (HPV) chemicals (chemicals that are produced in quantities of 1 million pounds or more per year). The EDF report found the following:
- Exposure to noise and the solvent toluene results in a higherrisk of hearing loss than exposure to either stressor alone.
- Common food colors are synergistically neurotoxicwith flavor enhancers at levels gotten from a typical snack and drink.
- Exposure to carbon monoxide and methylene chloride produces elevated levels of carboxyhemoglobin that reduce the blood’s ability to carry oxygen.
- Aluminum, copper, lead, mercury, and cadmium can be found in mussels at levels that, individually, are considered below the threshold of toxic harm. But these metals act synergistically with low concentrations of the mussel's own okadaic acid to kill cells.
- Viruses can increase susceptibility to heavy metals. And vice versa.
- In one study viral infection increased the uptake of PBDE.
- PBDEs, PCBs, and methylmercury are each synergistically toxic with the others. Very low exposures combine to induce greater than expected harm.
- In general, metals have synergistic toxicity — and organic metals have synergistic toxicity with organic compounds. Research indicates that low PCB exposure while in the womb, in combination with low exposure to methylmercury and lead, results in cognitive impairment.
- Exposure to a combination of 1 PCB, 2 dioxins, and 3 different pesticides means a person is 38x more likely to develop type-II diabetes than someone exposed to just 1 of the chemicals.
- Lupus clusters — the localized outbreaks of lupus at rates much higher than in the general population are associated with sites generating multiple chemical exposure. In one example the rate of lupus was 30x to 99x higher for people living in a 6-block area built atop a retired oil field waste pit. Key contaminants were determined to be mercury, pristane, and phytane.
- Tungsten and cobalt together can be carcinogenic and together have been found to rapidly accelerate the growth of human leukemia cells.
- Titanium dioxide nanoparticles are being used in an expanding range of products. These nanoparticles have been observed to greatly enhance the accumulation of cadmium in fish.
- Melamine and cyanuric acid are both considered non-toxic at low doses. But if those low doses combine in the kidneys, a fatal amount of crystals can form. Melamine and cyanuric acid were added to wheat gluten used as an ingredient in animal chows that caused the death of hundreds of pets in early 2007. Similar meals have been fed to farmed chickens, pigs, and fish. In September 2008 melamine was identified in at least 22 brands of Asian baby formula after an unusually high incidence of kidney stones were reported in infants, including several deaths. In November 2008 melamine and/or cyanuric acid were identified in several major brands of U.S. baby formula (Abbot Labs = Similac, Mead Johnson = Enfamil, Nestle = Good Start). Initially the FDA stated that any amount of exposure to melamine is unsafe for infants, but later asserted that 1 ppm melamine or 1 ppm cyanuric acid is safe as long as both chemicals are not present at the same time. Whether these levels are truly safe enough for infants remains unknown.
- Rats who drank milk retained 2x more mercury in their bodies than rats who didn't.
- The dust shed by automotive tires contains a mixture of chemicals. These chemicals act in synergy with each other.
- Microscopic particles in diesel exhaust combine with lipids in cholesterol to activate genes that trigger inflammation of blood vessels, in turn leading to atherosclerosis, heart attacks and strokes.
- Thallium is synergistically toxic with sodium hydrogen phosphate, a buffering agent commonly used in vaccines.
- Phthalates from cosmetics and vinyl plastic
- Brominated flame retardants (PBDEs) from televisions and furniture,
- Perfluorinated chemicals from stain-resistant and non-stick coatings
- Bisphenol-A from reusable water bottles and baby bottles
- Toxic metals such as lead, mercury and arsenic
|•||For 71% of the HPV chemicals we do not have in the public record even the simplest health and safety facts. This means that only 29% of high-volume chemicals had basic health hazard screening data, as established by the Organization for Economic Cooperation and Development.|
|•||Of the sampled chemicals known to be released into the environment — the Toxic Release Inventory chemicals — 51% are not even minimally screened for health hazards. This means that even for chemicals which have at least one recognized health hazard, we generally don't know if they have other health hazards because they have not been adequately screened.|
|•||Carcinogenicity tests are missing for 63% of HPV chemicals.|
|•||Reproductive toxicity tests are missing for 53% of HPV chemicals.|
|•||Neurotoxicity tests are missing for 67% of HPV chemicals.|
|•||Immune system toxicity tests are missing for 86% of HPV chemicals.|
|•||Studies for assessing impacts on children have not been done for more than 90% of HPV chemicals.|
|•||58% of the sampled HPV chemicals have not been tested for any form of chronic toxicity.|